![]() ![]() The number of publications on core-shell NPs increased rapidly starting from the 1994 and exceeded 1000 publications in the 2010 alone, with magnetic core-shell NPs being one of the pillar of this scientific branch from the very first studies on hetero-structured semiconductors up to the latest ones reporting on their use for the most advanced biomedical applications. Anna Tampieri, in Core-Shell Nanostructures for Drug Delivery and Theranostics, 2018 9.5 Future perspectiveĬore-shell NPs, and magnetic ones in particular, are the objects of a rapidly and continuously growing interest from the research community working on nanomaterials for the most different applications, from energy and data storage to advanced cell therapy. Additionally, stimuli-responsive core-shell nanofibers were designed as well, and among these, core-shell nanofibers produced with pH-sensitive polymers are of great importance for efficient targeted release of bioactive molecules.Īlessio Adamiano. Similarly, loading sweeteners to the shell of the nanofibers is an alternative approach to mask the bitter taste of the drugs loaded in the core. Moreover, core-shell nanofibers are especially useful for loading multiple bioactive molecules to manipulate the release rate of several bioactive molecules. Core-shell nanofibers were also found to be superior in terms of preserving bioactivity of the bioactive molecules loaded in the core alone or with other means such as liposomes, against exposure of solvents for long time. Triaxial nanofibers with an intermediate polymer layer were also developed to further decelerate the release of bioactive molecules. Addition of bioactive molecules in the shell as well, playing with the concentration of the bioactive molecules in the core and shell, cross-linking the system, addition of nanospheres, using several compounds in the core to increase the interaction with the bioactive molecules and thus to delay the release of bioactive molecules. There exist various methods to obtain controlled release with this type of nanofibers other than loading the bioactive molecules in the core of the nanofiber. The main advantages of this approach are making possible to obtain nanofibers from unspinnable solutions homogenous distribution of the bioactive molecules in addition to mitigation of the burst release, prolonged sustained release. Zeynep Aytac, Tamer Uyar, in Core-Shell Nanostructures for Drug Delivery and Theranostics, 2018 13.9 ConclusionĬore-shell nanofibers produced via electrospinning technique were shown to be an effective strategy for controlled release of bioactive molecules including drugs, proteins, and genes. 9.4 shows the SiC/SiO 2 core-shell nanoparticles with uniform inner diameter of 70 nm and outer shell thickness of 5–15 nm. successfully synthesized SiC/SiO 2 core-shell nanoparticles by a two-step process that involved the fabrication of SiC core nanoparticles covered with a Si shell by CVD process, followed by the oxidation of the Si to form an amorphous SiO 2 shell. ![]() The other approach for the formation of core-shell nanoparticles is the simultaneous growth of cores and shells. The polyaniline shell was formed through the oxidation of the monomer molecules by ultraviolet-visible light irradiation. The SiC nanoparticles were first dispersed in a solution of the aniline monomer and the sulfuric supporting electrolyte. For instance, photocatalytic deposition of a conducting polyaniline on the surface of SiC nanoparticles was reported by Kormányos et al. One of the approaches for the synthesis of SiC core-shell nanoparticles is the coating of the SiC nanoparticles. Core-shell nanoparticles composed of a SiC core encapsulated by another shell material were also synthesized, because they are expected to have properties that differ from the intrinsic properties of both materials. ![]()
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